{"id":8800033,"date":"2026-09-09T13:26:27","date_gmt":"2026-09-09T13:26:27","guid":{"rendered":"https:\/\/www.costamedicalservices.com\/spain\/medical-library\/glp-1-weight-management\/"},"modified":"2026-09-09T13:26:27","modified_gmt":"2026-09-09T13:26:27","slug":"glp-1-weight-management","status":"publish","type":"page","link":"https:\/\/www.costamedicalservices.com\/sv\/spain\/medical-library\/glp-1-weight-management\/","title":{"rendered":"What is a GLP-1 and how can it support weight management?"},"content":{"rendered":"<style>.entry-title{display:none!important}.cmsarticle{--ink:#103d56;--muted:#647d8b;--blue:#2d78da;--cyan:#1baec5;--green:#16856f;--line:#d9e7ed;--soft:#f3f8fa;--warn:#fff7e8;--rose:#fff3f3;--shadow:0 18px 44px rgba(16,61,86,.11)}\n.cmsarticle,.cmsarticle *{box-sizing:border-box}.cmsarticle html{scroll-behavior:smooth}.cmsarticle{margin:0;background:#fff;color:var(--ink);font-family:Inter,Arial,sans-serif;line-height:1.68}.cmsarticle a{color:#176ecb}.cmsarticle 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p{color:#c7d9e2}.cmsarticle .cta a{display:inline-block;padding:13px 18px;border-radius:12px;background:var(--blue);color:#fff;text-decoration:none;font-weight:850}.cmsarticle .disclaimer{margin-top:20px;padding:19px 21px;border:1px solid #cfdde4;border-radius:16px;background:#f7fafb;color:var(--muted);font-size:12px;line-height:1.6}.cmsarticle .disclaimer strong{display:block;color:var(--ink);font-size:13px;margin-bottom:5px}.cmsarticle .disclaimer p{margin:0}\n@media(max-width:850px){.cmsarticle .layout{grid-template-columns:1fr}.cmsarticle .toc{position:relative;top:auto}.cmsarticle .cards{grid-template-columns:1fr 1fr}.cmsarticle .related-grid{grid-template-columns:1fr}}\n@media(max-width:560px){.cmsarticle .page{padding:13px 15px 60px}.cmsarticle .hero{min-height:690px;padding:27px 21px;background-image:linear-gradient(0deg,rgba(255,255,255,.99) 0%,rgba(255,255,255,.95) 51%,rgba(255,255,255,.06) 75%),var(--hero);background-position:68% center}.cmsarticle .hero h1{font-size:40px}.cmsarticle .dek{font-size:17px}.cmsarticle .layout{gap:26px}.cmsarticle .summary{padding:22px 20px}.cmsarticle article{font-size:16px}.cmsarticle article h2{font-size:28px}.cmsarticle .cards,.cmsarticle .checklist{grid-template-columns:1fr}.cmsarticle .reviewer{grid-template-columns:56px 1fr}.cmsarticle .avatar{width:56px;height:56px;font-size:18px}}\n<\/style>\n<div class=\"cmsarticle\" lang=\"en-GB\">\n<div class=\"page\">\n    <a class=\"back\" href=\"https:\/\/www.costamedicalservices.com\/spain\/medical-library\/\">\u2190 Return to the Medical Library<\/a><\/p>\n<header class=\"hero\">\n<div class=\"hero-copy\">\n<div class=\"eyebrow\">Weight loss \u00b7 background medical guide<\/div>\n<h1>What is a GLP-1 and how can it support weight management?<\/h1>\n<p class=\"dek\">A complete explanation\u2014without easy promises\u2014about how these treatments work, what the doctor values, and what it means to use them with follow-up.<\/p>\n<div class=\"tags\"><span>GLP-1<\/span><span>semaglutide<\/span><span>tirzepatide<\/span><span>weight control<\/span><span>obesity<\/span><\/div>\n<div class=\"byline\"><span><strong>Reading:<\/strong> 12 minutes<\/span><span><strong>Updated:<\/strong> August 30, 2026<\/span><span><strong>Medical review:<\/strong> Dr Paola Blanco<\/span><\/div>\n<\/p><\/div>\n<\/header>\n<div class=\"layout\">\n<nav class=\"toc\" aria-label=\"Article content\">\n        <b>In this article<\/b><br \/>\n        <a href=\"#resumen\">Summary and conclusions<\/a><a href=\"#que-son\">What are GLP-1<\/a><a href=\"#como-actuan\">How they act<\/a><a href=\"#indicacion\">Who are they valued for?<\/a><a href=\"#diferencias\">Semaglutide and tirzepatide<\/a><a href=\"#expectativas\">What to expect<\/a><a href=\"#seguridad\">Safety<\/a><a href=\"#seguimiento\">The clinical process<\/a><a href=\"#fuentes\">Official sources<\/a><br \/>\n      <\/nav>\n<article>\n<section class=\"summary\" id=\"resumen\">\n<div class=\"summary-label\">Summary and conclusions<\/div>\n<h2>The essentials in less than a minute<\/h2>\n<ul>\n<li>GLP-1-related medications influence biological signals linked to appetite and intake; They do not replace diet, physical activity or monitoring.<\/li>\n<li>Wegovy contains semaglutide. Mounjaro contains tirzepatide, which acts on GIP and GLP-1 receptors. They are not the same medication nor are they chosen solely for popularity.<\/li>\n<li>The European authorisation for weight control establishes BMI criteria and, in certain overweight people, the presence of weight-related health problems.<\/li>\n<li>Response and tolerance vary. The goal is not to find \u201cthe strongest injection,\u201d but rather an appropriate, safe and sustainable option for the specific person.<\/li>\n<li>They are prescription medications. The decision corresponds to the doctor after reviewing history, medication, contraindications, risks and objectives.<\/li>\n<\/ul>\n<\/section>\n<section id=\"que-son\">\n<h2>What does \u201cGLP-1\u201d really mean?<\/h2>\n<p>GLP-1 is the acronym for <em>glucagon-like peptide type 1<\/em>, a signal that the body produces naturally after eating. In simple terms, it is part of the communication between the intestine, the pancreas and the brain. Medications in this family mimic or prolong part of that signal.<\/p>\n<p>On the Internet, \u201cGLP-1\u201d is used as a general label for various treatments, but it is advisable not to confuse family, active ingredient and brand. Semaglutide is an active ingredient related to GLP-1. Tirzepatide acts on two receptors, GIP and GLP-1. Wegovy and Mounjaro are specific brands with their own instructions and Summaries of Product Characteristics (SmPCs).<\/p>\n<div class=\"answer\"><strong>Short answer<\/strong>\u201cGLP-1\u201d is not a single pen nor a guarantee of results. It is a pharmacological family within which there are differences that are clinically important.<\/div>\n<\/section>\n<section id=\"como-actuan\">\n<h2>How can they help control weight?<\/h2>\n<p>Weight control does not depend only on willpower. Appetite, satiety, response to food, sleep, other medications, illness, and environment all play a role. Treatments related to GLP-1 modify some of the signals that intervene in that system.<\/p>\n<div class=\"mechanism\" aria-label=\"Three areas involved in the effect of the treatment\">\n<div><b>\u2460<\/b><strong>Signs of appetite<\/strong><span>You can change when satiety appears.<\/span><\/div>\n<div><b>\u2461<\/b><strong>Intake<\/strong><span>You can provide smaller amounts of food.<\/span><\/div>\n<div><b>\u2462<\/b><strong>Complete plan<\/strong><span>Food, activity and monitoring remain essential.<\/span><\/div>\n<\/p><\/div>\n<p>European regulatory information describes effects on the regulation of appetite and intake. In practice, some people notice satiety sooner or less interest in large amounts of food. This can facilitate an energy deficit, but the medication alone does not decide the quality of the diet nor automatically preserve muscle mass.<\/p>\n<h3>It is not an isolated treatment<\/h3>\n<p>Official indications for weight control place these medications as a complement to a diet with fewer calories and greater physical activity. That is why a good plan is not limited to prescribing: it includes realistic goals, sufficient nutrition, adapted movement, monitoring of adverse effects and review of results.<\/p>\n<\/section>\n<section id=\"indicacion\">\n<h2>Who can it be valued for?<\/h2>\n<p>According to European information, Wegovy and Mounjaro are used for weight control in adults with obesity, or in overweight adults when there is at least one weight-related health problem. The exact criteria are expressed by body mass index (BMI), but BMI is not the only part of the assessment.<\/p>\n<p>The doctor also needs to know relevant history, digestive symptoms, pregnancy or pregnancy planning, usual medications, previous treatments, metabolic health, expectations, and any situation that may modify safety. A consultation does not guarantee a prescription: it allows you to determine if there is a reasonable indication and if additional information is needed.<\/p>\n<div class=\"safety\">\n<h3>Important<\/h3>\n<p>A person may be interested in treatment and still not be a suitable candidate. It may also be necessary to request an in-person review or tests before deciding. That is not an administrative obstacle: it is part of a responsible prescription.<\/p>\n<\/div>\n<\/section>\n<section id=\"diferencias\">\n<h2>Semaglutide and tirzepatide: similar, but not interchangeable<\/h2>\n<div class=\"compare\">\n<div class=\"medicine\">\n<h3>Semaglutide<\/h3>\n<p><small>Brand example: Wegovy<\/small><\/p>\n<p>It acts as an agonist of the GLP-1 receptor. The choice, regimen and monitoring must comply with the indication and official product information.<\/p>\n<\/div>\n<div class=\"medicine\">\n<h3>Tirzepatide<\/h3>\n<p><small>Brand example: Mounjaro<\/small><\/p>\n<p>It acts on GIP and GLP-1 receptors. It has its own schedule, presentations, precautions and tolerance profile.<\/p>\n<\/div><\/div>\n<div class=\"table-wrap\">\n<table>\n<caption>Practical comparison of the two active ingredients<\/caption>\n<thead>\n<tr>\n<th>Appearance<\/th>\n<th>Semaglutide<\/th>\n<th>Tirzepatide<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Receivers<\/strong><\/td>\n<td>GLP-1<\/td>\n<td>GIP and GLP-1<\/td>\n<\/tr>\n<tr>\n<td><strong>Cited brand<\/strong><\/td>\n<td>wegovy<\/td>\n<td>Mounjaro<\/td>\n<\/tr>\n<tr>\n<td><strong>Administration<\/strong><\/td>\n<td>According to prescribed guideline; authorised injectable weekly presentation<\/td>\n<td>According to prescribed guideline; authorised injectable weekly presentation<\/td>\n<\/tr>\n<tr>\n<td><strong>Election<\/strong><\/td>\n<td colspan=\"2\">It depends on indication, history, tolerance, concomitant medication, objectives and medical criteria.<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<div class=\"evidence\" aria-label=\"Average results of separate clinical trials\">\n<div class=\"evidence-head\">\n<h3>Average weight loss observed in studies<\/h3>\n<p>Different essays, with different durations and groups. This visualization is not a direct comparison between treatments.<\/p>\n<\/div>\n<div class=\"bars\">\n<div class=\"bar-row\"><span>STEP 1 \u00b7 semaglutide<\/span><\/p>\n<div class=\"track\">\n<div class=\"fill\" style=\"--w:71%\"><\/div>\n<\/div>\n<p><span class=\"value\">\u221214,9%<\/span><\/div>\n<div class=\"bar-row\"><span>SURMOUNT-1 \u00b7 5 mg<\/span><\/p>\n<div class=\"track\">\n<div class=\"fill\" style=\"--w:72%\"><\/div>\n<\/div>\n<p><span class=\"value\">\u221215,0%<\/span><\/div>\n<div class=\"bar-row\"><span>SURMOUNT-1 \u00b7 10 mg<\/span><\/p>\n<div class=\"track\">\n<div class=\"fill\" style=\"--w:93%\"><\/div>\n<\/div>\n<p><span class=\"value\">\u221219,5%<\/span><\/div>\n<div class=\"bar-row\"><span>SURMOUNT-1 \u00b7 15 mg<\/span><\/p>\n<div class=\"track\">\n<div class=\"fill\" style=\"--w:100%\"><\/div>\n<\/div>\n<p><span class=\"value\">\u221220,9%<\/span><\/div>\n<\/p><\/div>\n<p class=\"study-note\">STEP 1: 68 weeks, semaglutide 2.4 mg plus lifestyle intervention. SURMOUNT-1: 72 weeks, tirzepatide plus lifestyle intervention, adults without diabetes. Averages do not predict individual outcome.<\/p>\n<\/p><\/div>\n<p>Comparing just the mean percentage of weight loss from two studies can be misleading. Trial populations, duration, doses, monitoring, and criteria may be different. Furthermore, an average does not predict what will happen for a specific person.<\/p>\n<p>The useful question is not only \u201cwhich one loses the most?\u201d, but \u201cwhich one is indicated, what risks should I review, what can I maintain in the long term, and how will we know if it is helping me?\u201d<\/p>\n<\/section>\n<section id=\"expectativas\">\n<h2>What to expect during treatment<\/h2>\n<p>The experience is usually not linear. Appetite may change before weight. Some weeks show more variation than others, and daily weight can fluctuate due to hydration, salt, intestinal transit, or menstrual cycle. That is why monitoring must look at the trend and not at an isolated figure.<\/p>\n<h3>A reasonable expectation includes:<\/h3>\n<ul>\n<li>a progressive start and reviews before dose changes;<\/li>\n<li>possible digestive discomfort, especially during adaptation;<\/li>\n<li>check if the diet is still sufficient and balanced;<\/li>\n<li>maintain physical activity, with attention to strength and function;<\/li>\n<li>decide with the doctor if the benefit outweighs the adverse effects;<\/li>\n<li>plan maintenance, not just the loss phase.<\/li>\n<\/ul>\n<p>Copying someone else&#8217;s regimen, speeding up increases, or purchasing the medication outside the legal circuit can increase risk and eliminates essential controls on authenticity, storage, and monitoring.<\/p>\n<\/section>\n<section id=\"seguridad\">\n<h2>Safety: common effects and signs that should not be ignored<\/h2>\n<p>Gastrointestinal discomfort &#8211; such as nausea, diarrhea, vomiting or constipation &#8211; are among the effects described with these treatments. Its intensity and duration vary. If they cause difficulty drinking, signs of dehydration or significant worsening, you should consult.<\/p>\n<p>The Summaries of Product Characteristics (SmPCs) include warnings and situations that require individual assessment. These include a history or symptoms compatible with pancreatitis, certain gastrointestinal problems, concomitant use with some diabetes medications, and considerations related to pregnancy. The complete list depends on the product and should be reviewed in its official information.<\/p>\n<div class=\"safety\">\n<h3>Seek urgent care when appropriate<\/h3>\n<p>Severe and persistent abdominal pain, continuous vomiting, shortness of breath, swelling of the face or throat, fainting or other serious symptoms should not be resolved by an article or a routine online consultation. Contact emergency services.<\/p>\n<\/div>\n<\/section>\n<section id=\"seguimiento\">\n<h2>What a responsible clinical process should be like<\/h2>\n<div class=\"journey\">\n<div class=\"step\"><b>1<\/b><strong>Prevaluation<\/strong><span>Goals, BMI, history, medication and exclusion signs.<\/span><\/div>\n<div class=\"step\"><b>2<\/b><strong>medical consultation<\/strong><span>Individual clinical review and decision on testing or treatment.<\/span><\/div>\n<div class=\"step\"><b>3<\/b><strong>Prescription if appropriate<\/strong><span>Only when the doctor considers that there is an indication and safety.<\/span><\/div>\n<div class=\"step\"><b>4<\/b><strong>Pharmacy<\/strong><span>Legal dispensation; The medication is not included in the consultation.<\/span><\/div>\n<div class=\"step\"><b>5<\/b><strong>Progressive start<\/strong><span>Use in accordance with the prescribed guidelines and product instructions.<\/span><\/div>\n<div class=\"step\"><b>6<\/b><strong>Tracking<\/strong><span>Tolerance, evolution, diet, activity and maintenance plan.<\/span><\/div>\n<\/p><\/div>\n<p>Helpful follow-up asks about both benefits and problems. If the person can barely eat, loses weight too quickly, has persistent effects, or has no benefit, the plan should be revised. Continuing \u201cbecause it is fashionable\u201d is not a clinical criterion.<\/p>\n<\/section>\n<section>\n<h2>Questions to bring to the consultation<\/h2>\n<ul>\n<li>Do I meet the indication criteria for weight control?<\/li>\n<li>Is there any history or medication that changes my risk?<\/li>\n<li>Do I need analysis or other evaluation before starting?<\/li>\n<li>What effects are expected and which require help?<\/li>\n<li>How will we measure benefit and when will we review the plan?<\/li>\n<li>What strategy will we use to conserve muscle mass and maintain results?<\/li>\n<\/ul>\n<\/section>\n<section class=\"reviewer\">\n<div class=\"avatar\" aria-hidden=\"true\">P.B.<\/div>\n<div>\n<h3>Reviewed by Dr. Paola Blanco<\/h3>\n<p>Responsible for the medical team in Spain \u00b7 Membership number 292891820. Clinical review and verification of official sources on August 30, 2026.<\/p>\n<p><span class=\"seal\">\u2713 Medically reviewed content<\/span><\/div>\n<\/section>\n<section class=\"sources\" id=\"fuentes\">\n<h2>Official sources and revision date<\/h2>\n<ol>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/wegovy\">European Medicines Agency: Wegovy, general and product information<\/a>.<\/li>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/mounjaro\">European Medicines Agency: Mounjaro, general and product information<\/a>.<\/li>\n<li><a href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/1211608006\/1211608006_ft.pdf\">AEMPS\/CIMA: Wegovy Summary of Product Characteristics (SmPC)<\/a>.<\/li>\n<li><a href=\"https:\/\/cima.aemps.es\/cima\/pdfs\/es\/ft\/1221685037\/FT_1221685037.html.pdf\">AEMPS\/CIMA: Mounjaro Summary of Product Characteristics (SmPC)<\/a>.<\/li>\n<li><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2032183\">Wilding et al.: STEP 1 trial with semaglutide, New England Journal of Medicine<\/a>.<\/li>\n<li><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2206038\">Jastreboff et al.: SURMOUNT-1 trial with tirzepatide, New England Journal of Medicine<\/a>.<\/li>\n<\/ol>\n<p>Last editorial check: August 30, 2026. Regulatory information may change; It will be reviewed again when the official sheets are updated.<\/p>\n<\/section>\n<section class=\"cta\">\n<h2>Do you want to know if a treatment may be right for you?<\/h2>\n<p>A medical consultation allows you to review your situation, resolve doubts and decide if tests or a prescription are needed. Prescription is never guaranteed.<\/p>\n<p>          <a href=\"https:\/\/www.costamedicalservices.com\/spain\/weight-loss-injections\/\">See weight loss consultation \u2192<\/a><br \/>\n        <\/section>\n<aside class=\"ai-disclaimer\" aria-label=\"Notice on artificial intelligence and medical information\"><strong>Editorial transparency and medical notice<\/strong><\/p>\n<p>This article has been prepared with the help of artificial intelligence tools and may contain errors, inaccuracies or omissions. Its content is provided for general information and guidance only. It never replaces a medical consultation, diagnosis or individualised treatment. Do not start, stop, or modify any medication or delay urgent care based solely on this content. Always consult your questions with a qualified doctor or pharmacist.<\/p>\n<\/aside>\n<aside class=\"disclaimer\"><strong>Notice about AI and medical information<\/strong><\/p>\n<p>This article has been prepared with the help of artificial intelligence and may contain errors, inaccuracies or omissions. It is offered as general guidance and never replaces medical consultation, examination, diagnosis, product information or pharmaceutical advice. 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